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Using a sliding window analysis, we observed that, on average, nucleotide diversity was lowest at approximately 300 bp upstream of the transcription start site, suggesting that this region may harbor important functional elements.

These genomic loci associated with many distant genes are biologically interesting since they may harbor important regulators.

The remaining transcription units map to genomic loci that were previously unannotated, but may harbor important genetic information and support important functions within the TNFα response in cardiomyocytes.

Derived allele frequency analysis of primate-specific HCNSs showed that these HCNSs were under purifying selection, indicating that they may harbor important functions.

Several studies have shown that 8p12 is a common region of amplification and may harbor important breast cancer oncogenes [ 5, 44- 46].

The implications for transmission of these mycobacteria to cattle or domestic pigs, with whom feral pigs often come into contact, are unclear, but in light of the fact that feral swine may harbor important veterinary pathogens (such as Brucella spp ., further investigation may be warranted [ 24, 25].

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Evidence suggests that this chromosome segment may harbor genes important in the development and progression of solid tumors.

Second, our experiments were designed to identify candidate mutations and polymorphisms in both coding and key non-coding regions, such as evolutionarily conserved sequences that may harbor functionally important and disease-causing variants (Drake et al. 2006).

QTL for hypocotyl length in this region, on the bottom of chromosome 4, have been previously identified in another RIL population in white, blue and red light conditions, suggesting that this region of the genome may harbor a QTL important for seedling light responsiveness [38].

Alternatively, the distinct RhoGEFs may differentially activate ROCK family members (ROCK1/β and ROCKII/α), which in turn may harbor subtle, but important differences in specificity towards IRS-1.

Because the deletion was generated close to the N-terminus, which may harbor the sorting signal, it is important to show that the truncated OspC can be successfully sorted to the outer surface of B. burgdorferi.

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