It is known that histologically normal margins may harbor genetic changes also found in the primary tumor, as shown by studies in HNSCC, including oral carcinomas [ 7].
Since histological status of surgical resection margins alone is not an independent predictor of local recurrence [ 5], histologically normal margins may harbor underlying genetic changes, which increase the risk of recurrence [ 6, 7].
In that study, all five patients were seronegative prior to transplantation, suggesting that normal seropositive donors may harbor and transmit multiple CMV strains or that the transplant recipients were susceptible to multiple exposures.
Interestingly, PF-derived fibroblasts express these ECM components in a similar fashion to fibroblasts from active disease, suggesting that even apparently normal fascia in DC patients may harbor an incipient disease phenotype.
We also show that these tumor samples exhibit high expression of p53 compared with their adjacent normal tissues, indicating that these tumors may harbor mutant p53.
Moreover, our normal liver samples were tumor-adjacent tissues, which may harbor genetic changes of tumor microenvironment, and therefore may not reveal the actual molecular characteristics of a tumor-free normal liver.
We can speculate that 1CT7 and A1309 cell lines may harbor a higher presence of aberrantly methylated genes compared to their normal isogenic counterpart, 1CT cells.
In addition, findings from PCPT revealed that about 15% of men with normal DRE and a serum total PSA less than 4.0 ng/mL may harbor prostate cancer [ 30].
Growing evidence suggests the adult heart may harbor resident stem and progenitor cells that participate in adaptive responses to myocardial injury, and possibly in cellular homeostasis under normal conditions.
Yet some worry that other innovations may harbor health threats.
