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Conversely, each mRNA may harbor multiple miRNA targeting sites (Ala et al., 2013).

There is emerging evidence that each tumor may harbor multiple genes susceptible to promoter hypermethylation.

Since tumors may harbor multiple mutations it is difficult to assess whether observed associations are specific for tumors with a particular gene defect.

Some viral genomes present in the inoculum may harbor multiple mutations, but since these would be genetically linked, they should be found in the same plaques derived from each cell.

A meta-analysis on selection gradients [ 34] suggests that disruptive selection might be as common in nature as stabilizing selection, suggesting that many adaptive landscapes may harbor multiple adaptive peaks.

The goal of the present study was to use expression analysis and next-generation sequencing to evaluate positional candidate genes within this 3.1-Mb glucose locus, located on rat chromosome 1: 204.38–207.48 Mb, a complex region that may harbor multiple causal genes (Granhall et al. 2006; Solberg Woods et al. 2010, 2012).

Similar(54)

In that study, all five patients were seronegative prior to transplantation, suggesting that normal seropositive donors may harbor and transmit multiple CMV strains or that the transplant recipients were susceptible to multiple exposures.

This step-wise computational approach based on a cross-species comparison is applicable to any tumor type for which sufficient human and model system DNA copy number data exist, and in this instance, highlights that a single region of amplification may in fact harbor multiple driver genes.

This shows that even though CENPE has mutations in multiple subtypes, it may harbor different driver potentials in different subtypes.

The large number of candidate SNPs in these regions identified in multiple analyses indicate these two regions may harbor variants that are locally adaptive, with selection altering the frequency of nearby SNPs through genetic hitchhiking (Nielsen et al. 2005).

However, this raises a concern that genomic sequencing errors may cause false positive in the ASE data, even in genes that harbor multiple exonic SNPs.

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