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Exact(7)
In this regard, our data indicate that the gene may become inactivated by hypermethylation in individual cases of PCa.
Tumor suppressor genes (TSG) may become inactivated during tumorigenesis through hypermethylation of associated CpG islands, providing several survival advantages [ 5– 8].
The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products.
Not only are some kinases redox regulated, but their dephos-phorylating protein counterparts (phosphatases) may become inactivated in response to increased intracellular H2O2.
If there is no selective advantage in keeping the duplicated gene, then the gene may become inactivated by mutations (nonfunctionalization), reduced to a pseudogene and finally removed from the genome by deletion.
The methylation of Hcy to methionine is catalyzed by MTR using cobalamin (vitamin B12) as a cofactor, in which the MTR may become inactivated due to the oxidation of cobalamin cofactor [ 10, 13, 14].
Similar(53)
Another possibility is that the virus may have become inactivated in the mosquitoes or killed as the specimens were processed.
At higher concentrations of H2O2, the decolourisation of MO is lower since the crude enzyme may have become inactivated (Veitch 2004; Hollmann and Arends 2012) when the substrate is MO.
Given the fitness cost of expressing some R genes [45], unnecessary R genes may become rapidly inactivated [46].
If receptors for hCG are more sensitive in hybrids, an abnormally high dose of hCG may cause these receptors to become inactivated leading to a lack of response by the process of spermatogenesis.
Proviral activity may occur over long periods of time until they become inactivated by loss of promoter functionality due to host chromosome rearrangements, insertions, deletions or point mutations.
Related(20)
may become disabled
may become dormant
may become non
may become silent
may become idle
may become neutral
may become unused
may become unemployed
may become disconnected
may become binding
may become cynical
may become difficult
may become unstable
may become extinct
may become world-class
may become many
may become fragmented
may have inactivated
may become horny
may become political
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