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Identification of predictive factors that are linked to outcomes may allow modification of surveillance strategies for sub-groups of patients and the need for research in this area has been highlighted by an expert panel of ASCO[ 9 ].

Identification of this CSCs-like bone tropism signature in breast cancer patients may be a relevant prognostic factor for clinical outcomes and may allow modification of therapeutic regimens according to the breast cancer characteristics.

Availability of resources to implement the majority of strong SSC recommendations (grade 1A and 1B) may allow modification of current sepsis guidelines based on available resources and implementation of a substantial number of life-saving interventions into sepsis care in Africa.

Given that the degree of necrosis present has an effect on the probable outcome, yet is not possible to assess before surgery using conventional imaging modalities, there have been efforts to find novel techniques that may be able to determine the level of necrosis before surgery, which in turn may allow modification to treatment in those patients with a low necrosis fraction following induction.

However, availability of resources to implement the majority of strong SSC recommendations (grade 1a and 1b) and the sepsis bundles may allow modification of current sepsis guidelines based on available resources and implementation of a substantial number of life-saving interventions into sepsis care in Africa.

As each patient and tumour is unique, accurate assessment of response at an early stage may allow modification of treatment by intensifying therapy in non-responders with the aim of improving clinical outcome; or early termination of ineffective treatment to avoid unnecessary drug toxicity.

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Similar(53)

However, the program's design, covering core EM content, may allow easy modification for medical students, residents in other specialties, and/or midlevel providers to facilitate task-shifting.

This may provide direct evidence of positive and negative clonal selection and the detection of emerging clones carrying drug-resistance mutations may allow early modification of treatment strategies before clinical progression occurs.

It has been suggested that there is a 'therapeutic window of opportunity' in which early treatment may allow the modification of underlying disease processes and the prevention of development of further inflammation [ 9- 11].

In this study the negative predictive value (NPV) was 64.3%, which the authors suggested may limit the usefulness of PET in the follow-up of residual masses although the high positive predictive value (PPV) may allow for modification of management in a small group of patients.

For instance the requirement that a Turing machine may only access or modify the tape cell which is currently being scanned by its read-write head may be generalized to allow modification to a machine's state at a bounded distance from one or more computational loci.

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