Both transcription factors (CREB and CRE-BP1) also interact with CREB binding protein (CBP /p300 associating factor, which, as CRE-BP1, is a known HAT or histone acetyltransferase [ 43, 44] and may promote chromatin modifications by inducing histone acetylation.
Given that extensive repatterning of histone modifications occurs during the reprogramming process, modulation of the deposition and removal of histone modifications may promote greater reprogramming efficiency.
Implant surface modifications may promote cell attachment, cell growth, and bone formation which ultimately enhances the osseointegration process.
More information is needed on the effectiveness of training/practice programmes which may promote improved function, and of environmental modifications to facilitate engagement of children with VND with the surroundings.
Indeed, as many as 35% of patients with an advanced stage of ALD (but not heavy drinkers with steatosis only) show the presence of a T cell proliferative response against lipid peroxidation protein adducts [ 340, 343], suggesting that oxidative modifications of epitopes may promote both humoral and cellular immune responses.
Surface modification of titanium implant may promote the bone healing process.
Perhaps the open conformation of WASP allows binding to other partners involved in podosome dynamics and/or it may allow further subsequent post-translational modifications of WASP that may promote cleavage by the protease calpain and subsequent dissolution of podosomes.
With HAMP, the Treasury Department tried to derail the foreclosure express by improving servicers' incentives to promote modifications instead.
These data implicate hyperglycemia induced modifications in arterial proteoglycans that may promote atherosclerosis.
Several previous studies have shown that enhancing O-GlcNAc modification of the NF- κB subunit may promote expression of its related genes [ 39, 40].
