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Direct activation of PAR-1 by the APC-EPCR complex is another mechanism by which APC may affect inflammation [ 6].
Thus, thiazolidinediones may affect inflammation rapidly, before the effects on insulin resistance have occurred, through mechanisms independent of improved insulin sensitivity [ 47- 51].
One possible way of investigating whether hyperuricemia may affect inflammation and tendon metabolism is to expose primary tendon cells to hyperuricemic PRP in vitro.
Furthermore, such details are obviously important to understand in the context of a potential clinical utilization of surfactant treatment to down-regulate systemic inflammation as well as to understand the mechanisms by which surfactant may affect inflammation.
Similar(56)
The results imply that simvastatin may affect inflammation-induced colon cancer proliferation via alteration of the equilibrium between pro- and anti-inflammatory cytokines.
Aldosterone is proinflammatory, making it likely that by blocking aldosterone spironolactone may beneficially affect inflammation and pain.
Obesity is associated with inflammatory responses in adipose tissues [3], and such tissues may affect systemic inflammation through the release of a pro-inflammatory cocktail of cytokines and chemokines.
Lastly, the type of sedation during spontaneous breathing and paralyzing agents during mechanical ventilation may affect lung inflammation [ 14, 15].
If such associations are causal and not a result of residual confounding, it is unclear how fetal exposure to 25(OH) D may affect chronic inflammation (via supply of the active molecule 1,25(OH)2D).
The IFN-γ and IL-33 studies support the same conclusion as the current study: that Th1 or Th2 cells (and possibly Th17 or Treg cells) may affect WAT inflammation, adiposity and glucose and insulin tolerance, but do not affect body weight gain.
The induction of VEGF expression by miR-146a may affect angiogenesis and inflammation during OA pathogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com