Delays in diagnosis and disease-specific therapy may affect disease outcomes and overall prognosis in affected individuals because of progressive neurodegeneration (1, 3, 23).
We further demonstrated that mutations within this epitope may affect disease progression in CHB.
This incomplete penetrance of PAH suggests multi-faceted genetic, epigenetic and/or environmental factors may affect disease expression (Ma and Chung, 2014; Austin and Loyd, 2014).
It is known that angiogenesis and inflammation are closely integrated processes in OA, which may affect disease progression and pain [24].
The field inoculation techniques are inherently poor in terms of reproducibility as a result of uneven inoculum distribution, interaction with other pathogens, and variations in weather and other environmental factors which may affect disease severity.
Epigenetic factors which have the potential to trigger neuroinflammation, including environmental exposures and age-associated chronic inflammatory conditions, will be discussed as possible 'second-hit' triggers that may affect disease onset or progression of idiopathic PD.
Thus, the mutation of IRF-5 in CLL patients may affect disease progression and immunotherapies through compromising IRF-5 transactivation activity.
Thus, cytotoxic interference of immune response induction by N-α-Syn may affect disease progression as these processes are shared by both effector and regulatory T cells.
This suggested that mice expressing H-2b have the potential to develop immune responses to N-α-Syn that may affect disease progression.
Studies in animal models, and twin and association studies have evidenced that the innate immune responses to pathogens show inter-individual variability that is strongly influenced by genetic factors, which may affect disease susceptibility and severity [3], [4], [5].
This raises the possibility that in RA T helper cell subsets may play different roles at different stages of disease or depending on genetic background of patients, which may affect disease activity or outcome.
