Sentence examples for may activate signalling from inspiring English sources

In airway smooth muscle, muscarinic agonists may activate signalling pathways such as the Rho kinase, PI3K or MAPK pathways [ 2].

Conversely, severe oxidative stress and increasing amounts of ROS may activate signalling pathways that lead to autophagy-induced cell death.

We suggest that increased cytoplasmic mTORC1 complex may activate signalling to cytoplasmic S6K1 and 4E-BP1 and contribute to tumour progression, although 4E-BP1 and S6K1 were not investigated in this study.

ECM is composed of a complex mixture of macromolecules and a variant of secreted molecules, such as growth factors, that through binding to specific ECM molecules and membrane receptors may activate signalling pathways that control or alternate cell behaviours [ 4].

This suggests that c-erbB-3 and c-erbB-4 may activate signalling pathways that are different from those activated by EGFR and c-erbB-2, or an additional pathway may be needed to induce transformation.

Finally, we demonstrated that elevated phosphorylation of PDK-1 was frequently found in high-grade metastasised breast tumours and was significantly associated with increased phosphorylation of its downstream kinases (P<0.05), indicating phosphorylation of PDK-1 may activate signalling cascades, which altogether contribute to breast cancer.

Cell-cell interactions are relevant in modulating the response to external stimuli, and modifications of membrane and/or matrix components may activate signaling events that change cell fate [34].

In any case, the lack of ObRb upregulation in our studies excludes this potential mechanism and suggests that most probably amylin may activate signaling pathways downstream of Jak2.

As TNF is released and mediates retinal damage after IR (Berger et al., 2008), TNF may activate signaling cascades that facilitate RGC programmed necrosis (necroptosis).

These data suggest that lack of this prosurvival factor in the cell medium may activate signaling that leads to cell demise, prompting future studies on the relationship between cell survival and developmental cell death that involves autophagy in insects.

In ARC neurons hyper-activation may lead to receptor down-regulation, attenuation of central signals and subsequent resistance, whereas in the heart, leptin may activate signaling through various receptor isoforms, and disperse modulatory and/or feedforward stimulation for up-regulated signaling intermediates.