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In addition, CSPGs may modulate signalling of growth promoting factors (e.g. Koprivica et al. 2005).
In order to answer the question whether TRD treatment may modulate signalling pathways common in several different tumour types rather than being tumour cell type specific we subjected the above described different cell lines (HT29 (colon), Chang Liver (liver), HT1080 (fibrosarcoma), AsPC-1, BxPC-3 (both pancreas)) to global gene expression analyses using Agilent microarray technology.
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It is now thought that Tie1 may modulate signaling through Tie2 [ 65- 67].
Besides, the enriched signal transduction process suggests that alternative splicing may modulate signaling pathways to exert its influence on cellular function networks.
PTPRC is a member of the protein tyrosine phosphatase family that has a role in antigen receptor signaling, B cell development and may modulate signaling via integrins and cytokine receptors [ 66].
Alternatively, NRP1 may modulate signal transduction pathways that directly regulate tip cell behavior, such as cytoskeletal remodeling and filopodia extension.
Because Daple enhances non-canonical Wnt signaling that is initiated by FZDRs, we asked how Daple may modulate signals downstream of these receptors and wondered if they interact.
Although we do not discuss NO-mediated signaling in detail in this review, it should be noted that NO-dependent nitrosylation of cysteine residues in proteins may modulate signal transduction cascades in a manner analogous to the effects of cysteine oxidation [78].
Irreversible acute protein oxidation may also modulate signaling, secondary to the proteasomal degradation of the oxidized protein.
The Arabidopsis ARR1, ARR10 and ARR12 play key roles in CK signalling, and ARR2 may modulate ethylene signalling.
Since this receptor also binds Dab1, our findings raised the possibility that the Pafah1b complex may modulate Reelin signaling.
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