Sentence examples for maximal efficacy and from inspiring English sources

In contrast, drugs which target multiple targets will have maximal efficacy and minimal adverse effects [13].

This choice is based on maximal efficacy and reasonable tolerability (Figs. 1, 2).

The quantitative analysis and characterization of how the NPs' spectral peak wavelength and spectral broadness change upon interaction with cells will help guide NP design for maximal efficacy and safety in biological environments.

Considering this fact, a novel immunotherapy combining maximal efficacy and minimal side effects seeks to alter these inflammatory responses for treatment or prevention of the disease.

The use of a targeted drug carrier (e.g., a liposome) to release chemotherapeutic drugs specifically in the neighborhood of EGF-overexpressing tumors has the potential to achieve the treatment ideality of maximal efficacy and maximal specificity [11].

To allow these drugs to achieve the treatment ideality of maximal efficacy and maximal specificity, it is necessary to use a targeted drug carrier to deliver and release the drugs specifically at the right time and at the right location [1].

The results are corrected to remove artifacts due to cytotoxicity and parameters such as concentration for half maximal activity, maximum efficacy, and minimal response are used to make activity calls based on algorithms for specific assay types and platforms (Judson et al. 2010).

Thus, an M3-muscarinic receptor ligand designed for maximal efficacy in learning and memory, and thus showing stimulus bias towards receptor phosphorylation/arrestin, would not be expected to show a toxic/adverse response via muscarinic-mediated early phase insulin release.

Reduction of arthritis score and paw volume on Day 19 (maximal efficacy of therapy) and Day 28 of AA after treatment with PBS-liposomes, free DxM-P (3 × 1 mg/kg; Days 14, 15 and 16), or liposomal DxM-P (3 × 1 mg/kg; Days 14, 15 and 16) compared to AA/PBS (Experiment 1 corresponds to the data in Figure 1).

Further, the MOR-selective agonist DAMGO activated G proteins in brain membranes from Oprm1+/+, Oprm1+/mch and Oprm1mch/mch mice with similar potency (184 ± 33, 120 ± 27 and 184 ± 27 nM, respectively) and maximal efficacy (210 ± 11, 196 ± 16 and 199 ± 12 %, respectively) (Fig.  1c).

Mutations W206A45.54 and Y311A6.48 also resulted in decreases in the maximal efficacy (Emax) of 45.0 and 53.4%, respectively, for OxA and OxB.