(C and D ) Scatter plots comparing fitted Kd and maximal transcription rate (Tx rate) in relation to maximal expression (C ) and in relation to simulated spatial range of expression (D ).
For each gene model, the growth stage and the plant organ which showed maximal expression were ascertained and maximal expression profiles for growth stage and plant organs relative to the Arabidopsis gene models were constructed.
This time frame coincided with the acquisition of maximum rolling efficiency and maximal expression of CCR-2 and LFA-1 by monocytes.
We computed the density for a state space extended according to (2) by the cooperativity β, by the maximal expression rate Vmax and by both β and Vmax, i.e., with extended state space variables (x, β)', (x, Vmax)' and (x, β, Vmax)', respectively.
These results demonstrate that both ATF4 and Runx2 are essential for the maximal expression of Osx and are reminiscent of our previous study showing cooperative interactions between these two factors in regulating the Ocn gene [59].
Conversely, for cytochrome c oxidase, which is used only in respiration, all subunits had maximal expression at sunset and minimal expression at sunrise (Figure 6 and Table S4).
The lowest tissue specificity was found in genes with primary expression in embryo and muscle, while the highest τ was found in genes with maximal expression in skin and testes (Table 2).
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.g., CCNB1, PLK1) are coordinately induced and reach maximal expression levels between 8 and 24 hr, consistent with the timing of the histologic changes observed in Figure 6A.
