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Exact(9)
Maximal clinical score was calculated as the mean of the maximal clinical scores during the experimental period.
Each limb was graded, allowing a maximal clinical score of 16 for each animal.
Each limb was graded, resulting in a maximal clinical score of 48 per animal.
Each limb was graded independently, resulting in a maximal clinical score of 16 per affected animal [ 23].
In the PBS-treated group, EAE developed at day 10 after challenge and reached a maximal clinical score at day 14.
The first clinical signs appeared at day 9 (1.7 ± 0.6), and the maximal clinical score (8.9 ± 0.5) was obtained at day 13.
Similar(51)
Both the maximal clinical scores and the cumulative scores were significantly reduced in the NP-transplanted animals (Table 1).
The high-dose T-614 (20 mg/kg per day) and combination treatments almost completely suppressed progression; maximal clinical scores in these rats were 1.75 ± 0.9 at day 24 and 1.73 ± 0.8 at day 22, respectively (P > 0.05, versus day 12).
The clinical score in the high-dose T-614 and combined treatment groups was found to be statistically significantly lower than that in the control group at day 20; the maximal clinical scores in these two groups were 1.75 ± 0.975 and 1.75 ± 0.79, respectively (P < 0.05, versus vehicle).
Robust joint inflammation developed in animals receiving vehicle control, with a maximal mean clinical score of 14.2 reached by study day 10.
Eight days after adjuvant injection, when the rats were experiencing maximal clinical signs of arthritis with a score of 12 using the same hindpaw scoring system described above, treatment began.
Related(19)
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