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Pathogen recognition and capture triggers a cascade of signaling events that leads to DC maturation, which involves outgrowth of dendrites, increased expression of MHC class II and co-stimulatory molecules, secretion of cytokines such as IL-12 and migration into T cell areas of lymphoid organs to present peptide antigen to naïve T cells.
On the other hand, RBPs are essential for mRNA maturation, which involves the addition of a 7-methylguanosine cap at the 5'end of mRNA-precursors, the splicing-out of introns, editing, and the addition of a polyadenosine tail at the 3'end of the message.
TLR signaling causes the dendritic cells to become licensed and begin to undergo maturation, which involves induction of the chemokine receptor CCR7.
These DCs must undergo a "maturation", which involves expression of the chemokine receptor CCR7, and upregulation of the co-stimulatory molecule CD86.
Finally, the last step of angiogenesis is vessel maturation, which involves the recruitment of vascular supporting cells (pericytes and smooth muscle cells) and the formation of the basement membrane.
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Within the hematopoietic system, B cells are perhaps the cell lineage with a more dynamic DNA methylome during their maturation process, which involves approximately one third of all the CpG sites of the genome.
In addition to its function in spindle formation and cytokinesis Plk1 has a well established role in centrosome maturation at the G2/M transition, which involves the recruitment of additional γTuRCs from the surrounding cytoplasm.
Autophagosomes undergo a maturation process in animal cells, which involves the recruitment of the SNARE protein syntaxin 17 [ 22– 22].
The maturation of individual mRNAs from polycistronic pre-mRNAs requires posttranscriptional control, which involves two coupled co-transcriptional RNA-processing reactions.
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