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In addition, GPAT maturation which requires an ISC, is not affected in the more severe hFXNI154F clones.
The decrease in EP1 mRNA steady-state levels was likely due to inefficient mRNA maturation, which requires the RNAP-II-dependent SL RNA transcript.
The consequent defect in cellular ATP production was evident as a dramatic inhibition of autophagolysosomal maturation, which requires a high rate of ATP consumption to fuel lysosomal acidification.
It is possible that early seizures interfere with these stages of myelin maturation which requires investigation in a larger series, ideally incorporating neuroimaging.
DOI: http://dx.doi.org/10.7554/eLife.00220.014 We have shown that LRP4 ECD is sufficient to initiate NMJ formation at embryonic stages but not sufficient for postnatal maturation, which requires a progressive increase of MuSK activation.
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In other species, development of a colourless gametophyte is slow, so at maturation, which may require up to eight years, the fleshy gametophyte will have become buried in successive layers of humus.
As the bud expands, epsin along with Hip1R provide a link between actin nucleation and coat maturation, which is required for deep invagination.
The plastid transcripts undergo an extensive and complex maturation process that includes the splicing of introns and RNA editing which require specific proteins encoded exclusively in the nucleus.
Maturation of the frontal and parietal regions is of great importance for adequate processing of developed cognitive functions which require activation of these brain regions.
This dependence is most marked in migratory fish which require different environments for the main phases of their life cycle which are reproduction, production of juveniles, growth and sexual maturation.
Instead, we found that Flt3L-mobilized DC from cancer patients require a sequence of specific signals for maturation, which included initial treatment with granulocyte macrophage-colony stimulating factor followed by a combination of maturation signals such as CD40L and IFN-gamma.
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