Heat shock protein 90 (Hsp90) is a molecular chaperone which regulates maturation and stabilization of its substrate proteins, known as client proteins.
We further demonstrate that Mtf2-PRC2 represses canonical Wnt signaling, which regulates erythroid maturation by controlling critical differentiation genes, including Gata2, Fli1 and Myb.
Evaluation of purified iNKT cells revealed that TSC1 promotes T-bet, which regulates iNKT maturation, but downregulates ICOS expression in iNKT cells by inhibiting mTOR complex 1 (mTORC1).
The functional properties of the receptor depend on the subunit combination, which regulates synaptic maturation, neuronal plasticity, and survival.
One of the best characterized targets is the FUS3 transcription factor, which regulates seed maturation in Arabidopsis [ 37].
We [ 22] and others [ 23] have used mice with targeted deletion of LRP1 receptor associated protein (RAP), which regulates LRP1 maturation, as a means to reduce LRP1 levels in mouse models of Alzheimer's disease.
Of particular note for this study are the suspected roles for CLN3 in positioning and motility of late endosomal/lysosomal compartments and its interactions with Rab GTPases (guanosine triphosphate-binding enzymes), and also with Hook 1 which regulates endosome maturation (80, 81).
The latest example is a study out of Temple University that found that the "temporal gap between puberty, which impels adolescents toward thrill seeking, and the slow maturation of the cognitive-control system, which regulates these impulses, makes adolescence a time of heightened vulnerability for risky behavior".
Chondroitin 6- O-sulfate may regulate the maturation of parvalbumin-expressing interneurons through the incorporation of Otx2 [ 116], which regulates ocular dominance plasticity.
Meiotic maturation is brought about by steroids using redundant pathways involving synthesis of Mos, which regulates the activity of MPF (M-phase promoting factor).
