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We also discuss current challenges in the field, such as maturation of stem cell-derived cardiac patches and vascularization.
Examples include developmental processes, differentiation and maturation of stem cells, evolution of malignancy and other.
Examples include developmental processes, differentiation and maturation of stem cells, evolution of malignancy and other [ 1].
(ii) Maturation of stem cell-derived cardiomyocytes So far, hPSC-derived cardiomyocytes resemble in some aspects a foetal, relatively immature cardiac phenotype.
To our knowledge, the present study provides the first model that treats replicative senescence and maturation of stem cells as two independent processes.
This hypothesis explains the adverse effects of glitazones on the heart and other organs resulting from reversal of the action of androgens in directing the maturation of stem cells towards muscle, vascular endothelium, erythroid stem cells and osteoblasts, and away from adipocyte differentiation.
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In perennial tomato, the orthologue SFT has been shown to regulate diverse growth processes, such as the flowering, growth and termination cycles typical of perennial plants, leaf maturation, growth of stems, and the formation of abscission zones [ 48].
According to cancer stem cell hypothesis, tumors arise from maturation arrest of stem cells [42], which implies that signaling pathway for self-renewal and proliferation of stem cells is maintained till the late stage of differentiation.
To identify novel miRNAs involved in the maturation of adult stem cells and tissue progenitors, we undertook an intensive search for candidates in the Stem Cell Genome Anatomy Project (SCGAP) sequence data.
The maturation of intestinal stem cells is also regulated by the Notch signaling pathway representing another evolutionary conserved signaling system involved in maintaining colon epithelium homeostasis [2] [4], [15] [17].
We further demonstrate the biological activity of the ECM coatings to sustain and promote cell differentiation using two cell culture models: differentiation of the C2C12 mouse myoblast cell line and maturation of human stem cell derived cardiomyocytes.
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