The phrase "age of stem" is not correct in standard written English.
It seems to be a misspelling or misinterpretation of "age of STEM," which refers to the era focused on science, technology, engineering, and mathematics education and careers.
Example: "In the age of STEM, students are encouraged to pursue careers in technology and engineering fields."
Alternatives: "era of STEM" or "period of STEM".
There is considerable evidence that continuous replicative stress accelerates the ageing of stem cells, and that aged stem cells are characterised by compromised genome maintenance.
Harvard researchers have retracted a far-reaching claim they made in January that the aging of stem cells might be reversible.
The semantics of intrinsic (autonomous) versus extrinsic aging of stem cells is illustrated in Figure 3.
Senescence and aging of stem cells have been studied, but their regulation remains largely uninvestigated.
The most plausible explanation will be to allow for the increase in the mutation rate associated with the ageing of stem cells.
Certainly, stem cells can contribute to aging in different tissues as a reflection of their relative contribution to cell turnover and regeneration implying that organs with a low turnover should be minimally affected by aging of stem cells [ 3].
Such quick and robust "rejuvenation" also suggests that not much intrinsic "aging" has been experienced by these stem cells, or that the intrinsic aging of stem cells can be rapidly reversed (within 24 hours) after exposure to youthful molecular cues, for example, by activation of Notch [ 4].
In muscle, the loss of tissue regeneration with age is thought to be imposed by signaling changes in the satellite stem cell niche, and interestingly, the aging of stem cell niches is to some extent similar between muscle, brain, blood, and other tissues [ 1- 3].
In summary, this review demonstrates the growing importance of the 'ageing epigenome', with potentially far-reaching implications for understanding the effect of age on stem cell function and differentiation, as well as for disease prevention.
The descriptions of P. betle here do not match each other owing to the age of the stem.
