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Similarly, the activities of several other membrane-localized transporters persist throughout meiotic maturation in mouse oocytes, including the GLYT1 glycine transporter and the TAUT β-amino acid transporter [48], [49], both of which share with Ae2 dependence on Cl−.
Fibre cell differentiation and maturation in mouse and human lenses is associated with denucleation.
miRNA microarray analysis of TEC subpopulations revealed several epithelium-specific miRNAs that were upregulated upon mTEC maturation in mouse and human thymus.
First, Tyrp1 mutation or decrease in expression interferes with melanosome maturation in mouse melanocytes and, most interestingly, attenuates cell proliferation, without evidence of necrosis or apoptosis (Sarangarajan et al, 2000).
Similarly, an earlier study [ 12] confirmed the requirements of transcription and protein synthesis as requirements for GVBD in domestic animals (sheep, cattle and pigs) while neither event is required for the initiation of maturation in mouse oocytes.
Similar(55)
This reduced Wnt3a ligand expression and hence, reduced signaling, could be involved in delayed chondrocyte maturation in mice with Hoxd4 overexpression.
For example, loss of CELF1 in Xenopus embryos has been shown to impair deadenylation [37], [38], and CELF1 has been implicated in translational regulation during muscle maturation in mice [39].
Chronic PUFA supplementation also impairs Srebp1c maturation in mice, and thereby limits de novo lipogenesis.
A study in THBS3-null mice provided evidence for the role of THBS3 in the regulation of skeletal maturation in mice [ 29].
Linker histone H1foo is a distinct member of the H1 histone family that is present in mammalian oocytes and is essential for oocyte maturation in mice.
HOXA5 is temporally expressed in the mesenchymal component of the developing gut [ 55] and a loss of HOXA5 function can perturb intestinal maturation in mice [ 56].
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