Sentence examples for maturation efficiency of from inspiring English sources

Thus, the low maturation efficiency of mCherry makes correction based on the relative abundance of GFP and mCherry difficult.

Therefore, a priority in the development of a CF therapy is to increase the maturation efficiency of CFTR processing mutants.

To increase the maturation efficiency of CFTR processing mutants, it will be necessary to determine the mechanism of rescue of VX-809 and bithiazole-type correctors.

Although the poor maturation efficiency of genetically encoded fluorescent proteins presents a challenge, we show that its effects can be alleviated.

Our study traces these limitations to two factors: (1) the large size of fluorescent proteins relative to the usable FRET range, and (2) poor maturation efficiency of the mCherry fluorophore.

This is because the subunit stoichiometry within the Ndc80 complex ensures an equal number of donor and acceptor molecules in these strains (neglecting the poor maturation efficiency of mCherry).

To test this hypothesis, we ran Monte Carlo simulations to include 25% maturation efficiency for mCherry.

If mCherry maturation efficiency is significantly lower than that of GFP, then each kinetochore cluster will contain two GFP populations: GFP donors with and without a mCherry acceptor.

Immunoblot analysis of whole cell SDS extracts showed that ΔF508/V510D/ΔNBD2-A52 (Δ1197−1480) had a maturation efficiency (about 50%) that was similar to that of the full-length ΔF508/V510D mutant (about 50%; Figure 1, panel F).

Such differences in transcript accumulation can be the result of pri-miRNA transcription and maturation efficiency and/or miRNA stability within the RISC complex.

In the presence of E-4031, Kv11.1-wt+Kv11.1-mut channel trafficking may have been enhanced due to a pharmacological chaperone mechanism that is believed to drive enhanced channel maturation efficiency [16].