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Li and Zhang [95] reported that they successfully used Chitosan- and alginate-based nanofibrous matrices to mimic the ECM of articular cartilage that primarily consists of type II collagen and proteoglycans (glycosaminoglycan, GAG).

Therefore, the matrix remodeling capabilities of a panel of ovarian tumor cell lines was assessed using fibroblast-derived matrices, to mimic ECMs of in vivo environments [30].

Hence, we use higher order of the adjacency matrices to mimic random walks on these networks while keeping the nonnegative property at the same time.

Several recent publications have addressed the importance of incorporating ECM components into hydrogel matrices to mimic the native cellular microenvironment for cell survival, proliferation, and differentiation.

Many different groups have tried to manipulate the mechanical properties (e.g., stiffness, strength, and toughness) of scaffolds through the design of nanostructures (e.g., the inclusion of nanoparticles or nanofiber reinforcements in polymer matrices) to mimic bone's natural nanocomposite architecture.

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Biomaterial scaffolds routinely provide nerve cells with a physical support for cell growth and regeneration, yielding 3D extracellular matrix to mimic the in vivo cellular microenvironment.

Next, we conjugated five active peptides, which showed strong cell attachment activity in the each group, onto a single chitosan matrix to mimic the multiple activities of laminin-111.

One MMP in particular, MMP14 [also known as membrane-type 1 matrix metalloproteinase MT1-MMP ]], has been shown to be crucial for cell invasion and MT1-MMP ]esis in thase-dimensional type I collagen matrices used to mimic the interstitial ECM (Hotary et al., 2000; Sabeenet al., 2004).

Hydrogels have been developed as artificial extracellular matrixes (ECMs) to mimic native tissue microenvironments for various applications.

Successful bone tissue engineering generally requires an osteoconductive scaffold that consists of extracellular matrix (ECM) to mimic the natural environment.

One major goal of tissue engineering is to develop new biomaterials that are similar structurally and functionally to the extracellular matrix (ECM) to mimic natural cell environments.

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