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Indeed it is hard to imagine that such a biasing could leave unaltered the capability of the matrices to recreate the intronic occurrence-preference relationship (whose mutational underpinnings are themselves very unlikely to have been shaped by selection of a nature that would mimic a selection regime typical for coding regions).
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Recently, hyaluronic acid (HA) has been incorporated in collagen matrices in an attempt to recreate tissue specific microenvironments.
To expect in vivo like cellular response several investigators have used extracellular matrix proteins as templates to recreate in vivo microenvironment for the regeneration of hard tissues.
Our approach evidences that normal and tumor decellularized matrices constitute excellent scaffolds when trying to recreate complex microenvironments to understand basic mechanisms of disease or therapeutic resistance.
Therefore, additive Gaussian Rx-noise and Tx-noise were artificially generated and spatially colored according to matrices of Equations (37) and (38), respectively, to recreate the measured scenario.
Most groups that have attempted to incorporate a cancer–stromal cell mix (usually fibroblasts) into a 3-D matrix [14] have done so without trying to recreate the tissue architecture seen in vivo.
As thymic architecture plays a crucial role in naïve T cell development, a tissue specific scaffold that provides essential supporting matrix may assist in stem cell-based thymus regeneration to recreate complex organoids.
Despite the significant advances in the meniscus tissue engineering field, it is difficult to recreate the complex structure and organization of the collagenous matrix of the meniscus.
However, our field generally lacks the ability to recreate, in vitro, the heterogeneous patterns of cells and matrix which are hallmarks of native tissue.
The partial recreation of the native intronic occurrence-preference patterns in sequences at equilibrium under 64×4 matrices estimated from coding-region substitutions is also important because it indicates that these coding-region matrices have not been biased by coding-region selection to the point of being unable to recreate the native intronic patterns.
In order to recreate and model some of the cues defining the cell microenvironment in vitro, matrix engineering techniques have been developed to model cell-ECM or cell-cell interactions and integrate physical parameters (stiffness, topology, topography) [4].
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