Sentence examples for markers of proliferative from inspiring English sources

β-catenin and PCNA are useful markers of proliferative activity in colon carcinogenesis [ 27- 29].

This clearly shows that both Ki67 and cyclin A are equally reliable as markers of proliferative activity.

There are several single gene markers of proliferative activity; the one that is used most commonly in the clinic is Ki67 (which was also included in the proliferation gene set).

The specific aim in this study was to explore whether DE-exposure would affect pro-apoptotic and anti-apoptotic proteins and markers of proliferative responses in the bronchial airways.

In one study, the 5 year survival rate of patients with gastric adenocarcinoma was much poorer in those patients expressing two or more markers of proliferative activity that included MT, glutathione-S-transferase-π or P-glycoprotein (Monden et al, 1997).

Ectopic expression of PLK1 in cultured cells is oncogenic [ 9] and, consistent with this observation, elevated PLK1 levels occur in various human tumour types [ 10- 20], including breast cancers where it is associated with aggressive characteristics, such as vascular invasion, markers of proliferative activity and lack of detectable estrogen receptor [ 17, 21].

No significant DNase I hypersensitivity of the CNS2 was detected in proliferating NHEKs, in which a fragment spanning the promoter of the keratin 5 gene, a strongly expressed marker of proliferative keratinocytes, showed hypersensitivity (Fig. 2).

MiRNA targeting genes regulating cell cycle are clearly downregulated at ST, not affected at IT and upregulated at LT. GMNN, which negatively regulates cell cycle, and MKI67, which is an endogenous marker of proliferative cells, are putative targets of mmu-miR-483.

It has been used as a marker of proliferative activity in several human tumors, including MM.

The Ki-67 immunohistochemistry was analysed as a marker of proliferative activity in HCCs.

Accordingly, Pax6, a marker of proliferative GNPs, as well as Zic1 and Zic2 were highly expressed at NS+8.