Sentence examples for marker of bad from inspiring English sources

Cognitive deficits are present in a large majority of Bipolar Disorder (BD) patients and known to be a marker of bad prognosis.

Interestingly, SPARC overexpression by tumor-associated fibroblasts in pancreatic and lung cancer is also a marker of bad prognosis despite the fact that the malignant cells themselves are SPARC-negative due to promoter hypermethylation [33], [50].

Previous analysis of 8p12 subregional amplifications in breast cancer [ 5] pointed to the amplified FGFR1 subregion as the best prognostic marker of bad disease evolution among other 8p amplifications.

Whereas TGF β1 seems to be confirmed as a marker of bad prognostic in a number of human tumours such as colorectal (Tsushima et al, 1996; Picon et al, 1998) and prostatic (Ivanovic et al, 1995; Shariat et al, 2004) cancers, the impact of TGF β1 on the progression of breast cancer remains uncertain.

COX2 contributes to increased anti-apoptotic, pro-angiogenic, and metastatic potential in cancer cells, and deregulation of COX2 expression was associated with tumor progression, suggesting that COX2 overexpression induced by nuclear ErbB2/HER2 in cancer cells may be a marker of bad prognosis.

While, from the physiologist point of view, it is one of the most crucial intermediates of carbohydrate and nonessential amino acid metabolisms, for most physicians it is merely considered as a marker of bad prognosis significantly related to a high mortality rate in acutely ill patients [ 5, 6, 7].

As shown previously, a low Glasgow coma scale (GCS) and/or a focal neurological deficit at hospital admission were independent clinical markers of bad outcome among children with AES [ 18].

These profiles indicate that patients belonging to the sub-class of good responders 2 share some expression marker characteristics with good responders in general, but also some marker characteristics of bad responders.

To further characterize the mechanism of the PKC-dependent reduction in cell viability, one prosurvival (CREB phosphorylation) and one antiapoptotic marker (phosphorylation of Bad) was analyzed in more detail by western blotting.

To assess whether length of time from onset of illness to hospital admission was a prognostic marker for bad outcome, we used length of reported fever prior to admission as a proxy marker.

Of particular note is the demonstration that nuclear β-catenin is associated with a poor prognosis, and methylation of the inhibitors of Wnt signalling, the SRFPs, act as markers of a bad prognosis.