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Advanced imaging can also target the problems related to the use of one single marker for treatment response evaluation.
Use of DNA detection as a marker for treatment success and for the prediction of relapse requires confirmation.
Figure 11 illustrates the component planes for two variables, one a marker for treatment in case study 3, and one for donor J in the same case study.
CREB also target other genes, such as brain-derived neurotrophic factor (BDNF), that is significantly involved in depression, serving as potential marker for treatment together with P-CREB [6].
These findings, together with the fact that impaired corticosteroid receptor signaling is considered as key mechanism of the pathogenesis in depression, support the suitability of the combined dex/CHR test as a surrogate marker for treatment response in depression.
In a typical clinical setting of the year 2007, DTC irrespectively of the strong prognostic significance would only have a convincing clinical application if DTC were a surrogate marker for treatment efficacy.
Similar(21)
Studies have indicated CD44 to be a surrogate marker for treatment-resistant cells [24].
Tumor proliferation is a hallmark of the cancer phenotype and one of the useful markers for treatment response evaluation and prognosis in clinical oncology [28].
Therefore, these markers might serve as surrogate markers for treatment efficacy in clinical trials.
Therefore, these markers maintain their usefulness as state markers over time and might serve as surrogate markers for treatment efficacy in clinical trials.
However, to our knowledge, none of these techniques have previously been used in examining clinical response to IFNβ treatment in MS. We hypothesised that proteins which differ in abundance between the plasma proteome of clinical responders and non-responders to IFNβ could serve as clinical response markers for treatment with IFNβ.
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