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Pri-miR-221/222 represents a novel molecular marker and putative oncogene in this disease.
To assess how genetic variability was distributed across and within species we calculated a series of summary statistics for each marker and putative subspecies.
In these situations, association between marker and putative gene alleles might differ between the founding populations and origin of alleles should be accounted for in studies which estimate breeding values with marker data.
A practical problem that is raised to accurately infer LD from 'case and control' samples is the need for accurate estimates of allelic frequencies at both marker and putative disease loci.
They have argued for a two-stage evolution of senile amyloid plaques with a secondary development of local neurotoxicity, for which increased levels of BChE in the plaque structure may be a marker and putative toxic agent (Mesulam and Geula 1994).
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Hereafter, we use markers (including true and pseudo markers) and putative QTL interchangeably.
The genome was scanned every 2 cM between markers and putative QTL with a window size of 10 cM.
Subsequently, the physical distances between the developed EST-SSR markers and putative genes related to cold stress were also calculated.
These results suggest that LD between markers and putative QTL mostly does not extend across breeds at a 50 k marker density.
CIM analysis was performed using Model 6, scanning intervals of 1 cM between markers and putative QTLs with a window size of 10 cM.
A detailed map of markers and putative genes responsible for each trait variation is presented in Figure 3, and LD blocks onto which significant associations fall, obtained by HAPLOVIEW software, are shown in Figure 4.
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