We constructed a comprehensive genome map of directional selection by detecting selective sweeps using an FST-based approach that detects directional selection in lineages leading to the domesticated breeds and using a haplotype-based test that detects ongoing selective sweeps within the breeds.
The integrated map of positive selection from Akey et al. [ 23] suggested that positive selection targets encompass ~14% of the human genome and ~23% of all UCSC RefSeq genes.
Qanbari et al. [ 18] employed an extended haplotype homozygosity test and published a genome wide map of recent selection within the German Holstein dairy cattle population.
This study provides a high-resolution bovine genomic map of positive selection signatures that are either specific to one breed or common to a subset of the seven breeds analyzed.
Thus, mapping signatures of selection may not be a very effective alternative to GWAS for the identification of genomic regions influencing economically important traits, as the peculiar structure of livestock populations generates high background.
Left column: mean-count polar maps of a selection of the reconstructions performed.
