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Human myxovirus resistance protein 1 (MxA) is an interferon-induced dynamin-like GTPase that acts as a cell-autonomous host restriction factor against many viral pathogens including influenza viruses.
Interestingly, the Nicotiana benthamiana ortholog of RDR1 is an inactive natural variant, which has been postulated to be responsible for N. benthamiana's hyper-susceptibility to many viral pathogens [34].
For example, viruses have had devastating economic consequences on honey-bee and shrimp populations [1], [2], and many viral pathogens in humans, crops and livestock are vectored by insects.
Several studies have documented that long oligonucleotide DNA microarrays can detect simultaneously many viral pathogens [ 18].
Many viral pathogens depend on a constant supply of susceptible hosts because the viral infection causes either host death or durable immunity.
Nevertheless, for many viral pathogens, including the influenza virus, measles virus, human immunodeficiency virus-1 and many others, ADAR1 has been shown to enhance viral replication and proliferation [ 67].
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Many important viral pathogens of fish are members of the family Rhabdoviridae.
Class II fusion proteins have a conserved three-domain architecture and are found in many important viral pathogens.
In addition, EB-ELISA has been used for sensitive and specific detection of antibodies to many other viral pathogens [28] [32].
Ticks are the main transmission vectors of NSDV and many other viral pathogens and therefore pose a major threat to public health (6, 7 ).
(H epatology 2014 59 408 422) Many global viral pathogens encode essential ion channel proteins, so-called "viroporins," representing an important opportunity for antiviral development.
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many viral vectors
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