Sentence examples for many viral vectors from inspiring English sources

One of the main problem emerged to perform any dystrophin gene therapy consists in the extremely large size of its mRNAs, that exceeds the incapsidation limits of many viral vectors.

Many viral vectors for VIGS have been developed for various plant species [ 6, 7, 10, 19- 22].

A major drawback for many viral vector platforms is preexisting immunity against the vector itself, which can decrease or nullify the essential protective immune response, which results in vaccine failure.

There have been two subcategories of gene vectors including many viral and nonviral vectors.

As RNA has a short half-life and lacks the ability to integrate into genome, many problems with viral vectors are not encountered [ 14].

Among the many viral and non-viral vector systems capitalizing on the AAV integration machinery are those based on hcAd vectors [14], [38], [39].

Given the unpredictability of viral vectors, many researchers have switched to synthetic vectors composed of liposomes or more recently graphene derivatives.

In contrast to other vectors that are devoid of viral gene sequences, early generation adenoviral vectors encode many viral proteins in addition to the transgene; these may contribute to the immunogenicity of these vectors (Schagen et al, 2004).

Human iPSCs that morphologically and functionally resemble human embryonic stem cells (ESCs) have been generated from many somatic cell types by viral vectors expressing defined reprogramming factors since 2007.

Viral vectors fulfill many of these criteria due to their self-amplifying properties (ensuring a high-level expression of volume-filling markers) (Callaway 2008; van den Pol et al. 2009).

Many groups continue to develop recombinant viral vectors due to their efficacy in vivo, and many DNA vaccines with these vectors continue to be brought to trial.