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Although many regulatory sequences are known not to operate under these design principles, we attempted to recover CRMs that are by searching for local word profile clustering.
While the basic similarity of embryonic development between Drosophila and tephritids suggests that gene expression patterns during development will be conserved, it is not yet clear how many regulatory sequences are present in both Drosophila and tephritids.
In human, many regulatory sequences, including promoters, tend to have high G+C content [24], and, as predicted by the relationship between nucleosome preferences and base composition, nucleosome occupancy at human promoters and other regulatory sites in vivo correlates with G+C content (green traces in Figure 2).
However, many regulatory sequences in a genome are not translated into proteins while they may still be functionally and evolutionarily important.
TA is underrepresented in almost all prokaryotic genomes; this could be due to the fact that (i) TA forms the thermodynamically least stable DNA (allowing unwinding of the helix), (ii) RNases preferentially degrade UA dinucleotides in mRNA, and/or (iii) TA is part of many regulatory sequences [ 38].
Similar(55)
A common characteristic of many regulatory protein sequences is the presence of phosphorylation sites.
Genome-wide datasets consist of many thousand regulatory sequences.
Many of these regulatory sequences are non-palindromic [ 43, 44] and are unlikely to remain functional after inversion.
However many regulatory RNA gene sequences diverge between species, e.g., micC, micF and ryhB (see Rfam website [ 26, 27]), and analogous genes in other species can be missed, especially between distantly related species.
In particular, many exons and regulatory sequences of host genes, and even entire new RNA and protein-coding genes are derived from TEs, a phenomenon called molecular domestication (Volff 2006; Rebollo et al. 2012; Jacques et al. 2013; Kapusta et al. 2013).
Many genes contain intronic regulatory sequences that are important for gene expression [34], [35].
Related(20)
abundant regulatory sequences
several regulatory sequences
multiple regulatory sequences
many regulatory pathways
many such sequences
many regulatory issues
many different sequences
many other sequences
many regulatory circuits
many pivotal sequences
many regulatory networks
many regulatory veterinarians
many regulatory contexts
many variable sequences
many regulatory bodies
many regulatory positions
many regulatory loops
many regulatory frameworks
many regulatory challenges
many regulatory departments
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