Sentence examples for many regulatory circuits from inspiring English sources
Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation.
Since HSP90 clients are hubs of diverse signaling networks and participate in nearly every cellular function, HSP90s represent connectors for many regulatory circuits and link them to environmental impacts [ 36].
Protein phosphorylation and dephosphorylation represent a major form of reversible post-translational modification that controls many regulatory circuits in eukaryotes by modulating the conformation, activity, localization and stability of substrate proteins [ 68].
In addition, H2O2 complements, synergizes or antagonizes many cellular regulatory circuits by active interaction with other signals and plant hormones during growth, development and stress responses.
We propose that the apparent requirement for multiple, redundant sRNAs in many bacterial regulatory circuits is coupled to their stoichiometric mode of action.
In many cases, key mixed regulatory circuits involve miRNAs, TFs and common target genes.
Among the many inhibitory molecules organizing negative regulatory circuits, we decided to focus on c-Cbl, an E3 ubiquitin ligase belonging to the CBL family, and the adaptor protein Dok2, which regulate TCR-mediated signaling through two different mechanisms.
The tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding RNAs and microRNAs, that establish intricate gene regulatory circuits influencing many cellular responses beyond the prototypical control of cell cycle, apoptosis and DNA repair.
They successfully identified known simple and complex regulatory circuits and discovered many putative circuits.
Advanced cancer is a multifactorial disease that accumulates many genetic and epigenetic alterations affecting multiple distinct regulatory circuits within cells.
Many important evolutionary adaptations originate in the modification of gene regulatory circuits to produce new gene activity phenotypes.
