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In contrast, methods for learning regulatory networks based on explicit dynamical models are more complex and scale less gracefully, but are attractive as they may allow direct prediction of transcriptional dynamics and resolve the directionality of many regulatory interactions.
It is no doubt many regulatory interactions are not included in this predicted network.
Developmental gene expression databases contain large sets of genes with many regulatory interactions.
Our results indicate that networks reconstructed from time series gene expression data can contain many regulatory interactions which are not based on direct transcriptional regulation, but reflect regulation due to unobserved processes, e.g. protein-protein interactions.
Two other TFs, SP3 (51 targets) and NFκB1 (18 targets), also engage in many regulatory interactions, while the remaining TFs (HOXB7, PGR, SMAD6 and HLF) together account for only 10 regulatory interactions.
Similar(54)
Many intricate regulatory interactions have been selected for in biology to create this evolvability.
We learned that the Inferelator 1.0
Apart from retaining several previously known interactions (cross validated using AGRIS), many novel regulatory interactions during the cold stress response in A. thaliana were suggested.
These results are also consistent with our knowledge of biological mechanisms, because there are many additional regulatory interactions between PIC recruitment and the production of an elongated, mature, stable transcript that do not involve TFs.
The new paradigm of signal multiplexing by 14-3-3s 14-3-3s 14-3-3s help explain mightof thereforeatory interactions among protein kinases thelparexplainunding therapeutic strategies.
Many regulatory SLiM-mediated interactions are also controlled by one or more of the ~300 different known post-translational modifications (PTMs) [ 23], further increasing the complexity of switching mechanisms [ 17, 24].
Related(20)
many regulatory reactions
multiple regulatory interactions
many regulatory relationships
several regulatory interactions
diverse regulatory interactions
many regulatory agencies
many ecological interactions
many regulatory networks
many regulatory veterinarians
many significant interactions
many regulatory bodies
many regulatory positions
many regulatory loops
many real interactions
many regulatory challenges
many regulatory departments
many regulatory proteins
many daily interactions
many regulatory procedures
many regulatory abuses
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