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Additionally, the identification of promoter regions and a comprehensive review of available literature allowed the annotation of several regulatory interactions involving σ factors and transcription factors.
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It is of particular interest to note that several regulatory interaction sites identified for SERT appear to lie within these structured regions (see below).
As mentioned above, in several cases we could also fix the relative sign of the various regulatory interactions in the FFLs so that we could distinguish between coherent and incoherent FFLs.
Several specific regulatory interactions of YB-1 with mRNA transcripts have also been reported, including Interleukin-2 [42], Granulocyte-Macrophage Colony-Stimulating Factor [43], and YB-1 itself [44], [45].
EAE is a multifactorial disease and several regulatory regions and epistatic interactions that influence EAE have previously been demonstrated in the AIL [27], [28].
In addition, several new miRNA-mRNA regulatory interactions were identified to occur in UVB-induced senescence.
In Table 4 and in Table 3, we listed several examples for simple regulatory interactions.
Subsequent analysis revealed several well established miRNA-mRNA regulatory interactions including miR-101/Ezh2 miR-101/Ezh2idatherebye assay.
Within a certain domain, expression patterns are determined by the interaction of several regulatory elements, including promoters, enhancers and insulators.
We conclude that the cis-regulatory effects on 17q12-q21 gene expression result from interaction between several regulatory polymorphisms and epigenetic factors within the cis-regulatory haplotype region.
Our results are relevant for the development of predictive biomarkers for anti-EGFR therapy, and suggest that the clinical effects of KRAS are the result of a complex interaction of several regulatory mechanisms beyond the KRAS point mutation status.
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