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However, when interactions between the TAPs and all Plasmodium proteins were examined, far too many protein interactions were observed.
The RecQ C-terminal (RQC) domain of WRN, containing α2-α3 loop and β-wing motifs, is important for DNA binding and for many protein interactions.
While HTP methods can help to identify many protein interactions, their overlap is usually low, and even when combined were shown to result in a false negative rate of around 41% (Braun et al. 2009).
For proteins that interact with muscarinic receptor, Borroto-Escuela et al. [ 84] revealed many protein interactions in various signaling pathways that will allow a better understanding of the muscarinic interactome.
Proteins in the same pathway have been found to be present or absent in a genome as a group (Kelly et al., 2003; Pellegrini et al., 1999), and many protein interactions in the yeast network have also been identified for the corresponding protein orthologs in worm (Matthews et al., 2001).
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OPN has many protein interaction domains which are thought to play a role in the function of the protein.
Many protein interaction data sets were cross-validated with human gene co-expression profiles such as [ 40].
As the structure of PSD95 includes many protein interaction domains three PDZ, a single SH3 and a single GK domain it is possible that each domain controls specific behaviours by recruiting specific protein-binding partners.
This supports the idea that regardless of how many protein-protein interactions a protein participates in, each interaction affects the protein's rate of evolution.
Many protein-protein interactions (PPIs) are mediated by a short linear motif (SLiM) in one protein interacting with globular domains in another.
According to the complexity hypothesis, horizontal transfer of genes encoding proteins with many protein-protein interactions is relatively infrequent as compared to HGT of genes encoding proteins with fewer interactions [ 15, 16].
Related(20)
multiple protein interactions
several protein interactions
diverse protein interactions
many protein interfaces
many body interactions
many gene interactions
many protein variants
many protein functions
many protein isoforms
many protein translocases
many protein regulators
many protein pairs
many protein enzymes
many protein features
many protein systems
many protein targets
many protein fragments
many protein kinases
many protein components
many protein structures
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