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It is now known that multicomponent protein assemblies strictly regulate many protein functions.
Many protein functions are currently deduced through comparative sequence homologies and theoretical prediction on the basis of cell compartment distributions.
More and more experimental evidences showed that many protein functions depend on the unstructured rather than structured state.
Many protein functions can be addressed by these means and the mechanism of action of these molecular machines may be resolved down to the level of a single bond.
S-Nitrosylation plays an important part in the NO physiological process and is considered to be a post-translational modification that plays a regulatory role in many protein functions, similar to phosphorylation.
In particular, it is now clear that interdomain interactions provide autoinhibition for many protein functions including kinase activity, transcriptional activation, and nuclear localization (see, e.g., review by Pufall and Graves).
Similar(53)
Many proteins function in the crystalline state, making crystallography a tool that can address mechanism, as well as structure.
Many proteins function by binding to multiple partners.
Many proteins function within large multimeric complexes that are highly dosage dependent.
The redox features of iron make it a useful cofactor for many proteins functioning in respiration, photosynthesis, nitrogen fixation and DNA biosynthesis, to name a few.
More detailed analysis of the 'response to' interaction network identified many proteins functioning in, for instance, response to DNA damage or response to oxidative stress caused by the accumulation of reactive oxygen species (see Supplementary data site).
More suggestions(15)
many body functions
many protein variants
many protein isoforms
many protein translocases
many protein behaviors
many protein regulators
many protein pairs
many protein enzymes
many protein features
many protein systems
many protein targets
many protein fragments
many protein kinases
many protein components
many protein structures
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