Sentence examples for many primary cancers from inspiring English sources

EZH2 is essential for proliferation and amplified in many primary cancers, and is inhibited by AKT through phosphorylation at Ser21 (Cha et al., 2005).

FAK protein and activation levels are increased in many primary cancers and further increased in metastatic lesions [ 12- 23].

Tumor size tends to predict survival in many primary cancers; why it should also predict survival in patients with isolated adrenal metastasis is not clear.

Our data show that intron retention characterizes the transcriptomes of many primary cancers, indicating that globally abnormal RNA splicing is a common correlate of tumorigenesis even in the absence of direct mutational insults to the RNA splicing machinery.

For example, activation of Src-family kinases has been reported in many primary cancers such as those affecting the colon, GI tract, breast and brain (reviewed in ref. [ 8]), and activated Src seems to play a critical role in the recruitment of endothelial cells to sites of tumor angiogenesis [ 9- 11].

TGF-β signaling inhibits cell proliferation in a multitude of cell types, including normal endothelial, epithelial, hematopoietic, and neural cells, certain types of mesenchymal cells, and especially many primary cancer cells (Massague et al., 2000).

Due to overexpression in many primary human cancers, peptides and peptide receptors remain an interesting candidate for treating cancers through receptor targeting approach [ 36].

Clinically, this understanding will be of great interest given that TRAIL-R3 is highly expressed in many primary gastrointestinal cancers and that high TRAIL-R4 expression is associated with poor prognosis in breast cancer.

It is not clear why mitochondria might appear functionally normal in many types of cultured tumor cells but appear structurally abnormal when evaluated in the tumor cells of many primary malignant cancers.

Furthermore, after submission of this manuscript, Burns et al., have demonstrated that APOBEC3B expression also correlates with a T-C mutator phenotype in many primary breast cancer tumours (Burns et al., 2013).

Although the 'seed and soil' hypothesis (Fidler, 2003) certainly still holds, both anatomical proximity and anatomical connection seem to be dominant factors when the analysis of metastatic sites includes many more sites and many more primary cancer types.