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The SUMO conjugation pathway is highly conserved in eukaryotic evolution, and plays many key regulatory roles.
In opposition, there are many key regulatory factors that promote differentiation and eradicate pluripotency [1].
This was not an unexpected result, as many key regulatory elements of signalling pathways in mammalian cells are regulated by non-transcriptional controls [34], [35], and so do not appear as DE genes within microarray datasets.
In our earlier work this method was tested on a set of microarray gene expression data from psoriatic patients where it was able to correctly identify many key regulatory proteins whose relation to the disease is confirmed by independent studies [24].
Genetic analyses of Arabidopsis mutants have revealed many key regulatory genes in plant defense responses.
Evolutionarily conserved uORFs have been identified in transcripts of many key regulatory genes 30, 31, implying an important physiological role for these uORFs.
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They are also required for the activation of many key cellular regulatory and signaling proteins like kinases and transcription factors [ 68].
At the molecular level, virus proteins interact with many key cell cycle regulatory proteins, including cyclin-dependent kinase (CDK), cyclin-dependent kinase inhibitors, and cyclin proteins).
In this review, we highlight that many of the key regulatory pathways of the cell are recruited by motifs and that the ease of motif acquisition has resulted in large networks of co-regulated biomolecules.
PI3K-AKT-mTOR signaling is a central regulatory axis for many key cellular functions including cell cycle, protein synthesis and glucose metabolism.
To realize the transition from C3 to C4, systems biology will play a critical role in many aspects, including identification of key regulatory elements controlling development of C4 features and viable routine towards C4 using constraint-based modeling approach [ 47].
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