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The TMACC interpretation of the DHFR data set identified many key structural features for DHFR inhibition.
While opsins have undergone considerable divergence in amino acid sequence in the 600 million years since they originated in animals (Plachetzki et al. 2007), many key structural aspects remain conserved.
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The mycobacterial cell wall of M. tuberculosis is rich with many unique key structural components that are necessary for the mycobacteria to survive and grow within the human host, and has long been a target for anti-TB drug development.
Furthermore, while we know many key players, the structural basis for integrin binding or its functional significance often remains to be determined.
Flavonoid biosynthesis, which was controlled by many genes [ 30], and key structural genes in the flavonoid metabolic pathway were screened in this study.
The use of dissipative bonding material also helps reducing structural vibrations in many key applications.
Phosphorus is a key element for life that occurs in living cells as a structural part of many key biochemicals.
Tetramic acid derivatives constitute an important class of nitrogen containing heterocycles, and are key structural motifs in many natural products of terrestrial and marine origin.
Disulfide bonds are key structural features of many conformationally constrained natural or synthetic peptides.
Many key transcription factors, signaling molecules and structural proteins necessary for myogenesis and muscle growth have been identified.
Spiroketals, which are key structural units in many biologically active natural products, can also be obtained by gold(I -catalyzed I -catalyzedar hydroalkoxylatintramoleculariols and alkynetriols.
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