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When we applied our method to a set of 74 Drosophila melanogaster microRNAs, searching 3′UTR sequences of a predefined set of fly mRNAs for target sites which were evolutionary conserved between D. melanogaster and Drosophila pseudoobscura, we found that many key developmental body patterning genes such as hairy and fushi-tarazu are likely to be translationally regulated by microRNAs.
Similar to Drosophila blastoderm nuclei, the pluripotent properties of human embryonic stem cells are reflected by the presence of paused Pol II complexes on a wide number of genes, including many key developmental regulators [2].
It has emerged that many key developmental decisions are made during the very first stages of oogenesis.
Ci is a transcription factor regulating hedgehog (hh) genes, involved in many key developmental processes including wing development.
During the preimplantation period of embryonic development, the mammalian embryo exhibits dramatic morphological changes and many key developmental events take place.
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We have used this technique to assess the transcriptional complexity within the developing kidney subcompartments, identifying mRNA variants of many key kidney developmental genes.
The majority of active loci were expressed at moderate to high levels 10-500 RPKM) with many key kidney developmental genes detected within this range.
The sequences of many other key developmental genes and transcription factors are also found in the T. corallinus genomic data set.
Many of the key developmental signaling pathways that function in an epithelial-mesenchymal capacity are implicated in maintaining the adult intestinal homeostasis.
As many of these genes are key developmental regulators, the current model holds that PcG protein-mediated repression prevents inappropriate differentiation.
However, the developmental course of many key brain regions supporting face preferential processing in the human brain remains undefined.
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