Sentence examples for many intracellular pathways from inspiring English sources

Polyglutamine-expanded proteins cause disruption of many intracellular pathways including those in the endoplasmic reticulum (ER) leading to ER stress.

Siah proteins can interact with many intracellular pathways, including the scaffold proteins, transcriptional repressors and nuclear receptor corepressors and β-catenin.

The output of a variety of receptors could be regulated by Merlin using this general mechanism, potentially explaining the many intracellular pathways that have been reported to be affected by Merlin.

In addition, activation of many intracellular pathways may cause degradation of free troponin to lower molecular weight fragments, which are released into the systemic circulation because of increased membrane permeability [ 9, 11].

Many types of proteins are phosphorylated by GSK3 (Jope and Johnson, 2004) involving it in many intracellular pathways (Rayasam et al., 2009) and this, together with its prominent neuronal expression, leads GSK3 to be implicated in various neurological disorders including Alzheimer's Disease (Cohen and Goedert, 2004; Hernandez et al., 2009).

As a result of these interactions many intracellular signaling pathways are activated, including the RAS, AKT and STAT pathways [9], [10], [11], [12].

Enhanced intracellular free Ca2+ levels are known to lead to the activation of protein kinase C, which is involved in many intracellular signaling pathways [29].

As the cytoskeleton is involved in many intracellular signaling pathways, the cytoskeletal distortion and shrinkage need to be further studied for a long observation time in future studies.

Furthermore, as the cytoskeleton is also involved in many intracellular signaling pathways, it remains to be investigated whether the AuNPs induced cytoskeletal disruption leads to secondary effects [31].

GSK3β is constitutively active under its Tyr-216 phosphorylated form and regulates many intracellular signaling pathways.

Although we observed that CD28SA stimulation led to the activation of many intracellular signaling pathways it is important to note that CD28SAs do not fully activate human T cells.