Nuclear transport factor 2 (NTF2) mediates nuclear import of RanGDP, a central component of many nuclear trafficking pathways.
Many nuclear import pathways are not valid drug targets, due to lack of specificity in NLS-import factor interactions; however, the huntingtin NLS has a unique structured IVS that could be exploited as a binding region for small molecules.
Considering only genes encoding proteins with a known TF activity (Table 1 in bold), we correctly identified many nuclear receptors as specific regulators of these pathways (NR1H4, NR1I3, ESRRG, HNF4A).
Functional, rapid nongenomic effects involving acute signaling pathways have been described for many nuclear receptor ligands, though as yet no clear mechanisms exist linking nuclear receptors to these events.
Nuclear actin plays an important role in many nuclear processes.
This protein has been implicated in several nuclear pathways, mainly through its interaction with additional factors, many of them bona fide tumor suppressor genes.
As might be expected for a key regulatory enzymes that functions at the hub of many nuclear processes, PARP-1 is subject to the regulatory actions of upstream signaling pathways that can control PARP-1 activity and function.
ARNT, on the contrary, appears to be a common dimerization partner for many nuclear transcription factor proteins [ 53- 58], most probably playing the role of crosstalk integrator between diverse signaling pathways.
Many nuclear receptors regulate differentiation.
Finally, pathway analysis revealed distinct nuclear pathways enriched in each tissue.
