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Many genes affecting bone are also involved in tooth development.
Genetic screens in Drosophila have led to the identification of many genes affecting sleep, feeding and metabolism with conserved function in mammals.
Many genes affecting G2 M checkpoint were upregulated late after carboplatin paclitaxel treatment, consistent with the known paclitaxel effect on inhibition of microtubule spindle disassembly.
For such phenotypes, dysregulation of relevant neural circuits might be caused by disruption of single genes, but combinatorial effects of variations in many genes affecting shared pathways have also been proposed (Shaikh et al., 2011).
Interestingly, the gene deletions whose MDP have the strongest anticorrelation with his3∆ estrainsraincludelude many genes affecting telomere maintenance, DNA damage response, and cell-cycle control (bottom of File S5).
MAP3K7 can also interact with many genes affecting melanocyte development [ 31, 32], such as MITF [ 41], KIT ligand, B-cell leukemia/lymphoma 2 [ 42, 43], lymphoid enhancer binding factor 1 [ 44], and epidermal growth factor receptor [ 45, 46].
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Such ASRE treatment significantly decreased the number of nuclear foci in DM1 patient cells and can reverse the missplicing of many genes affected in DM1 patients.
For example, the genotype phenotype map can be described in terms of the number of traits the mutations at a gene affect (pleiotropy), how many genes affect the same trait (polygeny), distribution of effect sizes, etc.
A study reported in the 11 September issue of Proceedings of the National Academy of Sciences not only identifies many genes affected by a low-calorie diet but demonstrates that even a few weeks of light eating makes the gene activity of elderly mice resemble that of youngsters.
However, this analysis is generally "noisy" and likely to identify multiple interactions between the many genes affected by copy number change without necessarily picking the key pathways.
In addition, many genes affected by HDAC inhibitor are involved in regulation of membrane potential, a process linked to signal transduction in neurons.
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