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It is possible that many epistatic interactions exist between LOAD genes, of which relatively few combinations have been tested here.
We found a total of thirty-five main-effect genomic regions and many epistatic interactions controlling genistein, daidzein, glycitein and total isoflavone accumulation in seeds.
More recently, a genome-wide screen in D. melanogaster recombinant inbred lines (RILs) identified many epistatic interactions, two of which were shown to have major effects on fecundity (Corbett-Detig et al. 2013).
For instance, in 2009 Combarros et al. attempted to replicate more than 100 epistatic findings and were only able to replicate 27 [ 188], suggesting that many epistatic interactions may be false positives.
In other words, capacitors are best defined as genes with many epistatic interactions (in the classical genetic sense in which an allele at one locus masks the effect of a polymorphism at another), rather than as genes that increase mutational robustness.
Similar(55)
Although our model of thermodynamics is, by necessity, simplistic, it does include many realistic aspects, such as the need for considering differences between the free energy of the native state and a large ensemble of alternative states and the stability being a holistic function of many epistatic energetic interactions.
By focusing on these 28 SNPs, we may have missed many important epistatic interactions.
A more complex possible explanation is that selection could drive this skew through many negative epistatic interactions in the genome (alluded to in Gompert et al. 2012).
This implies that many negative epistatic interactions segregate in these hybrid fish populations despite the fact that intrinsic post-zygotic isolation is thought to be weak (Rosenthal et al., 2003).
This extreme, frequently observed in our analysis, further validated many of the epistatic interactions, as opposed to being artifacts due to a limited sample size.
From what we know, e.g. from the existence of divergent evolution, most landscapes are comparatively rugged, with many synergistic or epistatic interactions (i.e. the value of one variable can influence strongly the optimum value of another variable).
Related(18)
several epistatic interactions
extensive epistatic interactions
multiple epistatic interactions
many ecological interactions
many significant interactions
many epistatic effects
many genetic interactions
many such interactions
many real interactions
many lightweight interactions
many daily interactions
many many interactions
many epistatic pairs
many transient interactions
many awkward interactions
many other interactions
many epistatic deviations
many epistatic QTLs
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