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Exact(9)

Both tumor and background were manually outlined on the basis of an additional [18F]FDG scan, which was performed directly after the TKI-PET scan was finished.

Infarct volumes were manually outlined on diffusion-weighted MR images by an experienced neuroradiologist using an imaging analysis tool (functool, advantage windows, version 4.3; GE healthcare).

To calculate the erosion volume, erosions were manually outlined on coronal images, on all slices where visible.

Regions of interest were manually outlined on the ρw images and then applied to the T2 maps.

Profiles were manually outlined on each CT scan slice and each voxel was classified according to its gas/tissue ratio.

Rat brains were manually outlined on multiple planes of the PET summation images using the image analysis software PMOD 3.1 (Pmod Ltd ,Zürich, Switzerland) or Amide [ 18].

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Similar(51)

Fluorescence intensity of APPL1 in the cell nuclei (manually outlined based on the Hoechst staining) was calculated using the Metamorph 4.6 r10 program.

For quantitative evaluation, the lesion ROI (region of interest) was manually outlined based on the subtraction images at 1-min post-injection (sixth frame third frame), by a well-trained operator (DN) using an in-house program written in MATLAB.

Automated image registration eliminates the subjective manual slice-matching and manually outlined ROIs are required only once.

In summary, cells were manually outlined, and then fluorescence measurements within each cell were performed on background-subtracted, summed-intensity projections.

Color images were converted to 8-bit images and thresholding was performed on each picture to obtain a black (manually outlined total organ tissue or total tumor tissue) and white (background) image.

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