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Volumes of interest (VOIs) were manually drawn on the fused FDG-BL and 90Y-PET images.
The regions of interest (ROIs) were manually drawn on the cerebral cortex, striatum, hippocampus, thalamus, cerebellum, middle peduncle, and medulla oblongata.
Inner and outer choroid boundaries were manually drawn on horizontal raster SD-OCT scans, and choroidal thickness and volume maps were generated.
The inner and outer boundaries of the choroid were manually drawn on all B-scans to allow computation of thickness and volume values for the entire scanned region.
The MR contours, which were previously manually drawn on T2-weighted fat-suppression (T2FS) scans by Villiers et al., were obtained from the TCIA database [19, 20].
A simple set of 10 curves was manually drawn on each face model using the BrainSuite 14 software, taking roughly 5 minutes per model by a trained operator.
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An oval-shaped region of interest (ROI) was manually drawn for each node on the b1000 images and copied to the ADC map.
Using an in-house software package developed in the IDL Development Environment ITT Visual Information Solutionss, Boulder, CO), regions of interest (ROIs) were manually drawn to encompass the whole brain on each of the CBF maps to read out the average CBF within the ROIs.
Volumes of interest were manually drawn for each 64CuCl2 avid PCa lesion with a diameter > 1 cm on mpMRI in each patient.
VOIs were manually drawn (1) on the tissue including the biopsy site (prospective studies) or on the tissue surrounding the hollow excised biopsy site (retrospective studies) and (2) on the corresponding contralateral region.
Volumes of interest (VOIs) of organs were manually drawn based on the CT imaging data using PMOD software (Ver. 3.5).
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