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Tropomyosins contribute to the spatial and temporal regulation of the actin cytoskeleton in an isoform-specific manner, by regulating actin's association with a plethora of actin-binding proteins [ 34].
Adipogenin may function in a similar manner by regulating levels of lipid stores during adipogenesis.
Alternatively, ARF inhibits cellular growth in a p53-independent manner by regulating ribosomal biogenesis through nucleophosmin [3].
Together, these results suggest that IPS-1 induces anticancer activity in an IFNβ-independent manner by regulating TRAIL, BCL2, BIRC3 and PRKCE.
The transcription factor Bcl11b/Ctip2 promotes hippocampal progenitor proliferation and neural differentiation in a non-cell autonomous manner by regulating the expression of the cell adhesion molecule Desmoplakin.
For example, it regulates the concentration of intracellular cAMP concentration in a very complex manner by regulating activities of cAMP producing adenylate cyclases (AC) and cAMP hydrolysing enzyme phosphodiesterase (PDE).
Similar(51)
AtDOF4 is known to influence phenylpropanoid metabolism in an environmental and tissue-specific manner by positively regulating the production of hydroxycinnamic acids in the hypocotyl and flower buds, and negatively regulating flavonoid biosynthesis in pollen grains [ 36].
The S ci mutation appears to predominantly influence circadian rhythmicity in a cell-nonautonomous manner by directly regulating the expression of specific neuropeptides that, in turn, synchronize local networks within the SCN.
In Arabidopsis, ATHB-7 is transcriptionally regulated in an ABA-dependent manner and modulates ABA signaling by regulating the activities of PP2C and an ABA receptor gene [ 31, 32].
In this manner it is possible that, by regulating DA neuronal firing and subsequently changes to synaptic levels of DA, the HCRTs are poised to impact D2 autoreceptor activity thereby influencing D2 mediated DAT function and related sensitivity to cocaine.
In addition, 10a induced tumor cell apoptosis in a dose-dependent manner by up-regulating the expression of Bax and caspase-3 and down-regulating Bcl-2.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com