Sentence examples for manner by activating from inspiring English sources

On one hand, DNA methylation alterations may occur progressively in cancer in a directional manner by activating those genes with oncogenic activity and/or inactivating those genes with tumor suppressor activity and maintaining actively those changes in cancer cells.

By developing structure function combinatorial relations we showed that digitoxin targets cancer cells in a time and dose-dependant manner by activating pro-apoptotic and anti-proliferative signaling cascades that results in strengthening cellular adhesion and sequestration of key regulatory proliferation protein from the nucleus.

Moreover it is possible that sildenafil increases intracellular Ca2+ levels in a cGMP independent manner by activating K+ channels with large conductance (BKCa) [26].

On the other hand, it has been demonstrated that NICD can regulate the expression of many of its target genes in a transcription-independent manner by activating PI3K and MAPK signaling cascades [33] [34].

Furthermore, RBMS3 was found to induce apoptosis in a mitochondrial-dependent manner by activating caspase-9 and PARP.

TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a tumor-selective manner by activating the extrinsic apoptotic pathway.

Moreover, TGF-β can induce signaling and gene expression in a Smad-independent manner (for instance, by activating mitogen-activated protein kinases (MAPKs), PI3K-Akt/PKB, and small GTPase pathways) [ 2, 6].

The underlying mechanisms may include stimulating growth of tumor cells and stromal cells in an autocrine, paracrine, or exocrine manner [11], inhibiting tumor apoptosis by activating the necrosis factor-κB (NF-κB) pathway.

HLA-DR-expressing NK cells have been shown to present tetanus toxin and house dust mite-derived peptides to T-cell clones in an HLA-DR-restricted manner 18. Antigen bound by activating NK receptors can be internalised to class II MHC-loading compartments and processed for subsequent HLA-DR-mediated presentation leading to T-cell proliferation 19.

In particular, radiation induces tumor cell proliferation in a dose-dependent manner between 0.5 and 2 Gy by activating the phosphoinositide 3-kinase (PI3K /Akt pathway, most likely by stimulating EGFRs on tumor cells 13, 14.

The complexes formed play a critical role by activating the biocatalysts involved in the manner in which glucose is biochemically stored and released.