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This is in accordance with earlier observations that MeJA can inhibit light-inducible and photosynthesis-related genes [22] and indicates that the MeJA effect not only acts on the post-translational level but also affects light sensitivity in a indirect manner by preventing transcription of photosynthesis-related genes.

Therefore, we postulated that Spartin overexpression might act in a dominant negative manner by preventing Spastin from binding to hIST1.

AT inhibited activation of NFκB in a dose-dependent manner by preventing phosphorylation and degradation of the inhibitor protein IκBα.

Resveratrol has also been reported to induce relaxation of vascular tissues in both endothelium-dependent manner and endothelium-independent manner by preventing vascular remodelling and enhancing endothelial NO production [ 3, 4].

Subsequently, Pang and colleagues demonstrated that IGF-I also protects OPCs from TNFα (tumor necrosis factor α) cytotoxicity in a dose-dependent manner by preventing Bax translocation from the cytosol to mitochondria via activation of PI3K (phosphoinositide 3-kinase)/Akt (Pang et al., 2007).

We have also reported that YM175 and YM529 inhibit the growth of murine osteosarcoma cell lines in a time- and dose-dependent manner by preventing prenylation of small GTPases and might be subject to multi-drug resistance mechanism in osteosarcoma cells (Horie et al, 2006).

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The concept behind these devices is to maintain or restore intervertebral motion in a controlled manner, whether by preventing excessive spinal movement or by dampening the kinetic energy.

It trimmed funding for Medicare Advantage plans and altered the manner in which insurers operate by preventing them from excluding high-risk patients.

NCS-1 can directly interact with postsynaptic D2 receptors in a Ca2+-dependent manner and inhibit receptor desensitization by preventing its phosphorylation through G protein-coupled receptor kinase 2 (GRK2, also known as ADRBK1), and thus beta-arrestin-mediated receptor internalization (Kabbani et al., 2002).

The processing of caspase-9 induced by BFA in Nef-treated MDMs was inhibited in a dose-dependent manner, indicating that Nef may function by preventing the activation of caspase-9 via decreased release of mitochondrial cytochrome c.

We demonstrate that hmAb p6C01 is neutralizing by preventing furin cleavage of PA in a dose-dependent manner, but the mechanism of p6F01 is unclear.

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