Sentence examples for manifested by severe from inspiring English sources

Clinical analysis of the mock-vaccinated animals demonstrated the presence of symptoms, characterized by bilateral serous rhinitis observed at 2 dpc that increased in severity, as manifested by severe seromucous rhinitis (score 2 4) by 8 11 dpc, returning to normal by 22 dpc.

RA is an autoimmune disease manifested by severe joint inflammation, which leads to joint destruction.

This led to oxidative damage in proliferating cells, manifested by severe necrosis in rolled-leaf and fasciated stems.

Consequently, all infected animals were susceptible to T. vivax infection showing variable clinical and pathological changes, manifested by severe responses.

Abnormal liver functions as manifested by severe gastrointestinal problems and clinical elevations of liver enzymes in plasma including alanine amino transferase (ALT), asparatate amino transferase (AST), alkaline phosphatase (ALP) also are associated with chronic arsenic exposure [ 9, 15, 18].

In these patients, three tissues are predominantly affected: muscles, brain and liver, manifested by severe myopathy, slow myelination, developmental delay [61 63] as well as mild hepatitis [61] and lipid droplet accumulation in the liver [63].

It was reported that decline in total protein can be deemed as a useful index of the severity of cellular dysfunction in chronic liver diseases as manifested by the severe histopathological alterations of the liver tissue following DMBA treatment.

Higher doses could not be achieved without inducing unacceptable liver toxicity, as manifested by a severe inflammatory infiltrate and vacuolisation of the hepatocytes.

Traumatic brain injury (TBI) is associated with a profound immunological dysfunction manifested by a severe shift from T-helper type 1 (to1) T-helperper type 2 (Th2) response.

PD is manifested by (1) severe motor symptoms characterized by a progressive impairment of movement control, akinesia, rigidity, and tremor; and (2) nonmotor symptoms such as cognitive decline, olfactory dysfunction, anxiety [ 95], and depression [ 96].

The importance of SOD is manifested by the severe pathologies associated with lack of this enzyme in mouse models (Lee et al. 2013; Kliment et al. 2009; Behndig 2008).