Sentence examples for indicated by severe from inspiring English sources
Nonetheless, we found that HMDM and J774A.1 cell death was dependent on YopJ/YopP expression as indicated by severe membrane disruption and release of cytosolic components (Fig. 1 and Fig. 2).
In fact, adult hippocampal neurogenesis appears to be necessary for hippocampus-dependent learning and memory, as indicated by severe cognitive deficits following ablation of neurogenesis in mice models by toxins, x-ray irradiation or virus-activated pro-drugs [19], [20], [21].
No steroids were used unless indicated by severe vomiting.
Moreover, Shox2 has a crucial role in pacemaker function indicated by severe bradycardia with intermittent sinus exit block after morpholino-mediated knockdown in zebrafish embryos and markedly reduced heart beat rates of isolated Shox2− / − hearts [ 2, 12].
A high percentage of AD patients exhibit evidence of WM degeneration, as indicated by severe apoptotic loss of oligodendrocytes (Bronge, 2002) and free radical injury to myelin and axons (Back et al., 2011).
Quantitative RT-PCR analysis confirmed that the yoeB Spn -GFP fusion gene was expressed from day 1 after induction and RNA sampling stopped at day 7 because all the plants were dead by day 8 (indicated by severe discoloration of the rosette leaves in Figure 4A, 9dpin).
Although the exclusion of subjects with a history of recurrent severe hypoglycaemia from these trials may be another limitation, this criterion was enforced because the patients with hypoglycaemic unawareness (indicated by recurrent severe hypoglycaemia) may be unsuitable candidates for treatment to the glycaemic levels recommended for the general diabetes population.
The predictors for long MV might overestimate the true effect because these neonates are usually in poorer condition than those in the INSURE failure group, which is indicated by the more severe predictors (Table 2) and post-surfactant characteristics (Table 3).
Two prospective studies found that in specifically sensitized children, culturable airborne indoor Penicillium was associated with significantly increased outcomes of severe exacerbations (as indicated by unscheduled medical visits), severity, or symptoms (Gent et al. 2012; Pongracic et al. 2010), even after adjustment for outdoor fungal levels in one study (Gent et al. 2012).
In addition, we will examine the effects on other secondary outcomes including the risks of development of new or recurrent disease progression event, including all-cause mortality; ARV regimen change from first- to second-line therapy; and other adverse events as indicated by incident peripheral neuropathy, severe anemia, or diarrhea.
-wrap-foot> Investigated brain fiber tract, rating of axonal ataxin-3 pathology sorted by increasing severity (none: 0; slight: 1 5; marked: 6 10; severe: 11+) indicated by different shades of gray (ND not determined) Except for the external and extreme capsules and the hippocampal alveus, all of the evaluated brain fiber tracts were at least mildly affected by these axonal inclusions (Table 3).
